| Passing Leaders | |||||||||||
| PLAYER | TEAM | RESULT | COMP | ATT | YDS | TD | INT | SACK | FUM | RAT | |
Drew Brees |
1. Drew Brees, QB | NO | W 42-20 at MIN | 32 | 40 | 412 | 5 | 0 | 0 | 1 | 149.2 |
| 2. Matthew Stafford, QB | DET | W 28-27 at OAK | 29 | 52 | 391 | 4 | 0 | 2 | 1 | 105.5 | |
| 3. Carson Palmer, QB | OAK | L 28-27 vs. DET | 32 | 40 | 367 | 1 | 0 | 3 | 0 | 113.2 | |
| 4. Ben Roethlisberger, QB | PIT | L 20-3 at SF | 25 | 44 | 330 | 0 | 3 | 3 | 1 | 52.3 | |
| 5. Tom Brady, QB | NE | W 41-23 at DEN | 23 | 34 | 320 | 2 | 0 | 2 | 0 | 117.3 | |
| Rushing Leaders | ||||||||||
| PLAYER | TEAM | RESULT | CAR | YDS | AVG | TD | LNG | FUM | ||
Reggie Bush |
1. Reggie Bush, RB | MIA | W 30-23 at BUF | 25 | 203 | 8.1 | 1 | 76 | 1 | |
| 2. Donald Brown, RB | IND | W 27-13 vs. TEN | 16 | 161 | 10.1 | 1 | 80 | 0 | ||
| 3. Maurice Jones-Drew, RB | JAC | L 41-14 at ATL | 17 | 112 | 6.6 | 0 | 43 | 0 | ||
| 4. Arian Foster, RB | HOU | L 28-13 vs. CAR | 16 | 109 | 6.8 | 1 | 22 | 1 | ||
| 5. Felix Jones, RB | DAL | W 31-15 at TB | 22 | 108 | 4.9 | 0 | 38 | 0 | ||
| Receiving Leaders | ||||||||||
| PLAYER | TEAM | RESULT | REC | YDS | AVG | TD | LNG | FUM | ||
Calvin Johnson |
1. Calvin Johnson, WR | DET | W 28-27 at OAK | 9 | 214 | 23.8 | 2 | 51 | 0 | |
| 2. Brent Celek, TE | PHI | W 45-19 vs. NYJ | 5 | 156 | 31.2 | 1 | 73 | 0 | ||
| 3. Darrius Heyward-Bey, WR | OAK | L 28-27 vs. DET | 8 | 155 | 19.4 | 1 | 43 | 1 | ||
| 4. Roddy White, WR | ATL | W 41-14 vs. JAC | 10 | 135 | 13.5 | 2 | 29 | 0 | ||
| 5. Greg Little, WR | CLE | L 20-17 at ARI | 5 | 131 | 26.2 | 1 | 76 | 0 | ||
| Defensive Leaders | ||||||||||
| PLAYER | TEAM | RESULT | SOLO | AST | TOT | SACK | FF | INT | TD | |
Jason Pierre-Paul |
1. Jason Pierre-Paul, DE | NYG | L 23-10 vs. WSH | 11 | 5 | 16 | 1.0 | 0 | 0 | 0 |
| 2. Ernie Sims, LB | IND | W 27-13 vs. TEN | 8 | 7 | 15 | 0.0 | 0 | 0 | 0 | |
| 3. Jordan Senn, LB | CAR | W 28-13 at HOU | 12 | 2 | 14 | 0.0 | 1 | 1 | 0 | |
| 4. D'Qwell Jackson, LB | CLE | L 20-17 at ARI | 12 | 1 | 13 | 0.0 | 0 | 0 | 0 | |
| 5. London Fletcher, LB | WSH | W 23-10 at NYG | 10 | 2 | 12 | 0.0 | 1 | 0 | 0 | |
