| Passing Leaders | |||||||||||
| PLAYER | TEAM | RESULT | COMP | ATT | YDS | TD | INT | SACK | FUM | RAT | |
Philip Rivers |
1. Philip Rivers, QB | SDG | L 31-26 vs. BAL | 25 | 45 | 436 | 2 | 2 | 2 | 0 | 85.0 |
| 2. Kevin Kolb, QB | PHI | L 48-22 vs. NOR | 31 | 51 | 391 | 2 | 3 | 1 | 0 | 73.2 | |
| 3. Matt Schaub, QB | HOU | W 34-31 at TEN | 25 | 39 | 357 | 4 | 0 | 0 | 0 | 127.8 | |
| 4. Eli Manning, QB | NYG | W 33-31 at DAL | 25 | 38 | 330 | 2 | 0 | 0 | 0 | 110.6 | |
| 5. Drew Brees, QB | NOR | W 48-22 at PHI | 25 | 34 | 311 | 3 | 1 | 2 | 0 | 118.6 | |
| Rushing Leaders | ||||||||||
| PLAYER | TEAM | RESULT | CAR | YDS | AVG | TD | LNG | FUM | ||
Frank Gore |
1. Frank Gore, RB | SFO | W 23-10 vs. SEA | 16 | 207 | 12.9 | 2 | 80 | 0 | |
| 2. Chris Johnson, RB | TEN | L 34-31 vs. HOU | 16 | 197 | 12.3 | 2 | 91 | 0 | ||
| 3. Fred Jackson, RB | BUF | W 33-20 vs. TAM | 28 | 163 | 5.8 | 0 | 43 | 1 | ||
| 4. Cedric Benson, RB | CIN | W 31-24 at GNB | 29 | 141 | 4.9 | 0 | 14 | 0 | ||
| 5. Ronnie Brown, RB | MIA | L 27-23 vs. IND | 24 | 136 | 5.7 | 2 | 19 | 0 | ||
| Receiving Leaders | ||||||||||
| PLAYER | TEAM | RESULT | REC | YDS | AVG | TD | LNG | FUM | ||
Dallas Clark |
1. Dallas Clark, TE | IND | W 27-23 at MIA | 7 | 183 | 26.1 | 1 | 80 | 0 | |
| 2. Mario Manningham, WR | NYG | W 33-31 at DAL | 10 | 150 | 15.0 | 1 | 49 | 0 | ||
| 3. Andre Johnson, WR | HOU | W 34-31 at TEN | 10 | 149 | 14.9 | 2 | 72 | 0 | ||
| 4. Vincent Jackson, WR | SDG | L 31-26 vs. BAL | 6 | 141 | 23.5 | 1 | 38 | 0 | ||
| 5. Steve Smith, WR | NYG | W 33-31 at DAL | 10 | 134 | 13.4 | 1 | 32 | 0 | ||
| Defensive Leaders | ||||||||||
| PLAYER | TEAM | RESULT | SOLO | AST | TOT | SACK | FF | INT | TD | |
Barrett Ruud |
1. Barrett Ruud, LB | TAM | L 33-20 at BUF | 5 | 9 | 14 | 0.0 | 0 | 0 | 0 |
| 2. Kirk Morrison, LB | OAK | W 13-10 at KAN | 13 | 0 | 13 | 0.0 | 0 | 0 | 0 | |
| 3. Scott Shanle, LB | NOR | W 48-22 at PHI | 11 | 1 | 12 | 0.0 | 0 | 1 | 0 | |
| 4. Ray Lewis, LB | BAL | W 31-26 at SDG | 10 | 2 | 12 | 0.0 | 1 | 0 | 0 | |
| 5. Thomas Davis, LB | CAR | L 28-20 at ATL | 10 | 2 | 12 | 0.0 | 0 | 0 | 0 | |