| Passing Leaders | |||||||||||
| PLAYER | TEAM | RESULT | COMP | ATT | YDS | TD | INT | SACK | FUM | RAT | |
Peyton Manning |
1. Peyton Manning, QB | IND | W 31-10 at ARI | 24 | 35 | 379 | 4 | 1 | 0 | 0 | 130.5 |
| 2. Joe Flacco, QB | BAL | W 34-3 vs. CLE | 25 | 35 | 342 | 1 | 0 | 1 | 0 | 111.8 | |
| 3. Jason Campbell, QB | WAS | L 19-14 at DET | 27 | 41 | 340 | 2 | 1 | 2 | 0 | 97.6 | |
| 4. Kurt Warner, QB | ARI | L 31-10 vs. IND | 30 | 52 | 332 | 1 | 2 | 4 | 0 | 67.1 | |
| 5. Kevin Kolb, QB | PHI | W 34-14 vs. KAN | 24 | 34 | 327 | 2 | 0 | 0 | 0 | 120.6 | |
| Rushing Leaders | ||||||||||
| PLAYER | TEAM | RESULT | CAR | YDS | AVG | TD | LNG | FUM | ||
Pierre Thomas |
1. Pierre Thomas, RB | NOR | W 27-7 at BUF | 14 | 126 | 9.0 | 2 | 34 | 0 | |
| 2. Maurice Jones-Drew, RB | JAC | W 31-24 at HOU | 23 | 119 | 5.2 | 3 | 61 | 0 | ||
| 3. Steven Jackson, RB | STL | L 36-17 vs. GNB | 27 | 117 | 4.3 | 0 | 20 | 1 | ||
| 4. Correll Buckhalter, RB | DEN | W 23-3 at OAK | 14 | 108 | 7.7 | 0 | 34 | 1 | ||
| 5. Fred Taylor, RB | NWE | W 26-10 vs. ATL | 21 | 105 | 5.0 | 1 | 19 | 0 | ||
| Receiving Leaders | ||||||||||
| PLAYER | TEAM | RESULT | REC | YDS | AVG | TD | LNG | FUM | ||
Santana Moss |
1. Santana Moss, WR | WAS | L 19-14 at DET | 10 | 178 | 17.8 | 1 | 57 | 0 | |
| 2. DeSean Jackson, WR | PHI | W 34-14 vs. KAN | 6 | 149 | 24.8 | 1 | 64 | 0 | ||
| 3. Reggie Wayne, WR | IND | W 31-10 at ARI | 7 | 126 | 18.0 | 1 | 33 | 0 | ||
| 4. Vincent Jackson, WR | SDG | W 23-13 vs. MIA | 5 | 120 | 24.0 | 0 | 55 | 0 | ||
| 5. Derrick Mason, WR | BAL | W 34-3 vs. CLE | 5 | 118 | 23.6 | 1 | 72 | 0 | ||
| Defensive Leaders | ||||||||||
| PLAYER | TEAM | RESULT | SOLO | AST | TOT | SACK | FF | INT | TD | |
Curtis Lofton |
1. Curtis Lofton, LB | ATL | L 26-10 at NWE | 13 | 6 | 19 | 0.0 | 0 | 0 | 0 |
| 2. David Hawthorne, LB | SEA | L 25-19 vs. CHI | 15 | 1 | 16 | 0.0 | 0 | 1 | 0 | |
| 3. London Fletcher, LB | WAS | L 19-14 at DET | 11 | 5 | 16 | 0.0 | 0 | 0 | 0 | |
| 4. Barrett Ruud, LB | TAM | L 24-0 vs. NYG | 10 | 4 | 14 | 0.0 | 0 | 0 | 0 | |
| 5. Kevin Burnett, LB | SDG | W 23-13 vs. MIA | 9 | 4 | 13 | 1.0 | 0 | 0 | 0 | |