| Passing Leaders | |||||||||||
| PLAYER | TEAM | RESULT | COMP | ATT | YDS | TD | INT | SACK | FUM | RAT | |
Matt Schaub |
1. Matt Schaub, QB | HOU | L 28-21 at ARI | 35 | 50 | 371 | 2 | 1 | 0 | 0 | 96.3 |
| 2. Tony Romo, QB | DAL | W 26-20 at KAN | 20 | 34 | 351 | 2 | 0 | 1 | 1 | 113.7 | |
| 3. Kyle Orton, QB | DEN | W 20-17 vs. NWE | 35 | 48 | 330 | 2 | 1 | 2 | 0 | 96.7 | |
| 4. Matt Ryan, QB | ATL | W 45-10 at SFO | 22 | 32 | 329 | 2 | 1 | 0 | 0 | 110.0 | |
| 5. Peyton Manning, QB | IND | W 31-9 at TEN | 36 | 44 | 309 | 3 | 1 | 0 | 0 | 109.2 | |
| Rushing Leaders | ||||||||||
| PLAYER | TEAM | RESULT | CAR | YDS | AVG | TD | LNG | FUM | ||
Cedric Benson |
1. Cedric Benson, RB | CIN | W 17-14 at BAL | 27 | 120 | 4.4 | 1 | 28 | 0 | |
| 2. Jamal Lewis, RB | CLE | W 6-3 at BUF | 31 | 117 | 3.8 | 0 | 18 | 0 | ||
| 3. Ahmad Bradshaw, RB | NYG | W 44-7 vs. OAK | 11 | 110 | 10.0 | 2 | 24 | 0 | ||
| 4. Michael Turner, RB | ATL | W 45-10 at SFO | 22 | 97 | 4.4 | 3 | 33 | 0 | ||
| 5. Tashard Choice, RB | DAL | W 26-20 at KAN | 8 | 92 | 11.5 | 1 | 36 | 0 | ||
| Receiving Leaders | ||||||||||
| PLAYER | TEAM | RESULT | REC | YDS | AVG | TD | LNG | FUM | ||
Miles Austin |
1. Miles Austin, WR | DAL | W 26-20 at KAN | 10 | 250 | 25.0 | 2 | 60 | 0 | |
| 2. Roddy White, WR | ATL | W 45-10 at SFO | 8 | 210 | 26.3 | 2 | 90 | 0 | ||
| 3. Jeremy Maclin, WR | PHI | W 33-14 vs. TAM | 6 | 142 | 23.7 | 2 | 51 | 0 | ||
| 4. Kellen Winslow, TE | TAM | L 33-14 at PHI | 9 | 102 | 11.3 | 2 | 24 | 0 | ||
| 5. Andre Johnson, WR | HOU | L 28-21 at ARI | 8 | 101 | 12.6 | 2 | 21 | 0 | ||
| Defensive Leaders | ||||||||||
| PLAYER | TEAM | RESULT | SOLO | AST | TOT | SACK | FF | INT | TD | |
Kirk Morrison |
1. Kirk Morrison, LB | OAK | L 44-7 at NYG | 13 | 3 | 16 | 0.0 | 1 | 0 | 0 |
| 2. D'Qwell Jackson, LB | CLE | W 6-3 at BUF | 9 | 4 | 13 | 0.0 | 0 | 0 | 0 | |
| 3. Gibril Wilson, S | MIA | W 31-27 vs. NYJ | 11 | 1 | 12 | 0.0 | 0 | 0 | 0 | |
| 4. Patrick Willis, LB | SFO | L 45-10 vs. ATL | 6 | 6 | 12 | 0.0 | 2 | 0 | 0 | |
| 5. Leigh Bodden, CB | NWE | L 20-17 at DEN | 10 | 1 | 11 | 0.0 | 0 | 0 | 0 | |