| Passing Leaders | |||||||||||
| PLAYER | TEAM | RESULT | COMP | ATT | YDS | TD | INT | SACK | FUM | RAT | |
Ben Roethlisberger |
1. Ben Roethlisberger, QB | PIT | W 27-14 vs. CLE | 23 | 35 | 417 | 2 | 1 | 3 | 1 | 113.6 |
| 2. Matt Schaub, QB | HOU | W 28-17 at CIN | 28 | 40 | 392 | 4 | 1 | 2 | 0 | 124.2 | |
| 3. Joe Flacco, QB | BAL | L 33-31 at MIN | 28 | 43 | 385 | 2 | 0 | 3 | 0 | 109.2 | |
| 4. Tom Brady, QB | NWE | W 59-0 vs. TEN | 29 | 34 | 380 | 6 | 0 | 2 | 0 | 152.8 | |
| 5. Drew Brees, QB | NOR | W 48-27 vs. NYG | 23 | 30 | 369 | 4 | 0 | 0 | 0 | 156.8 | |
| Rushing Leaders | ||||||||||
| PLAYER | TEAM | RESULT | CAR | YDS | AVG | TD | LNG | FUM | ||
Thomas Jones |
1. Thomas Jones, RB | NYJ | L 16-13 vs. BUF | 22 | 210 | 9.5 | 1 | 71 | 0 | |
| 2. DeAngelo Williams, RB | CAR | W 28-21 at TAM | 30 | 152 | 5.1 | 2 | 20 | 0 | ||
| 3. Adrian Peterson, RB | MIN | W 33-31 vs. BAL | 22 | 143 | 6.5 | 0 | 58 | 0 | ||
| 4. Maurice Jones-Drew, RB | JAC | W 23-20 vs. STL | 33 | 133 | 4.0 | 3 | 26 | 1 | ||
| 5. Chris Johnson, RB | TEN | L 59-0 at NWE | 17 | 128 | 7.5 | 0 | 48 | 0 | ||
| Receiving Leaders | ||||||||||
| PLAYER | TEAM | RESULT | REC | YDS | AVG | TD | LNG | FUM | ||
Sidney Rice |
1. Sidney Rice, WR | MIN | W 33-31 vs. BAL | 6 | 176 | 29.3 | 0 | 63 | 0 | |
| 2. Marques Colston, WR | NOR | W 48-27 vs. NYG | 8 | 166 | 20.8 | 1 | 40 | 0 | ||
| 3. Hines Ward, WR | PIT | W 27-14 vs. CLE | 8 | 159 | 19.9 | 1 | 52 | 0 | ||
| 4. Wes Welker, WR | NWE | W 59-0 vs. TEN | 10 | 150 | 15.0 | 2 | 48 | 0 | ||
| 5. Zach Miller, TE | OAK | W 13-9 vs. PHI | 6 | 139 | 23.2 | 1 | 86 | 0 | ||
| Defensive Leaders | ||||||||||
| PLAYER | TEAM | RESULT | SOLO | AST | TOT | SACK | FF | INT | TD | |
David Harris |
1. David Harris, LB | NYJ | L 16-13 vs. BUF | 7 | 10 | 17 | 0.5 | 0 | 0 | 0 |
| 2. Keith Bulluck, LB | TEN | L 59-0 at NWE | 10 | 4 | 14 | 0.0 | 0 | 0 | 0 | |
| 3. C.C. Brown, S | NYG | L 48-27 at NOR | 12 | 1 | 13 | 0.0 | 0 | 0 | 0 | |
| 4. Leon Hall, CB | CIN | L 28-17 vs. HOU | 10 | 2 | 12 | 0.0 | 1 | 0 | 0 | |
| 5. DeMeco Ryans, LB | HOU | W 28-17 at CIN | 8 | 4 | 12 | 0.0 | 0 | 0 | 0 | |
