| Passing Leaders | |||||||||||
| PLAYER | TEAM | RESULT | COMP | ATT | YDS | TD | INT | SACK | FUM | RAT | |
Brett Favre |
1. Brett Favre, QB | MIN | L 27-17 at PIT | 33 | 50 | 334 | 0 | 1 | 4 | 1 | 76.6 |
| 2. Jake Delhomme, QB | CAR | L 20-9 vs. BUF | 27 | 44 | 325 | 0 | 3 | 2 | 0 | 55.6 | |
| 3. Tony Romo, QB | DAL | W 37-21 vs. ATL | 21 | 29 | 311 | 3 | 0 | 2 | 0 | 141.6 | |
| 4. Tom Brady, QB | NWE | W 35-7 at TAM | 23 | 32 | 308 | 3 | 2 | 1 | 0 | 107.3 | |
| 5. Drew Brees, QB | NOR | W 46-34 at MIA | 22 | 38 | 298 | 1 | 3 | 5 | 1 | 58.9 | |
| Rushing Leaders | ||||||||||
| PLAYER | TEAM | RESULT | CAR | YDS | AVG | TD | LNG | FUM | ||
Cedric Benson |
1. Cedric Benson, RB | CIN | W 45-10 vs. CHI | 37 | 189 | 5.1 | 1 | 26 | 0 | |
| 2. Ryan Grant, RB | GNB | W 31-3 at CLE | 27 | 148 | 5.5 | 1 | 37 | 0 | ||
| 3. Shonn Greene, RB | NYJ | W 38-0 at OAK | 19 | 144 | 7.6 | 2 | 33 | 0 | ||
| 4. Steven Jackson, RB | STL | L 42-6 vs. IND | 23 | 134 | 5.8 | 0 | 14 | 0 | ||
| 5. Thomas Jones, RB | NYJ | W 38-0 at OAK | 26 | 121 | 4.7 | 1 | 26 | 0 | ||
| Receiving Leaders | ||||||||||
| PLAYER | TEAM | RESULT | REC | YDS | AVG | TD | LNG | FUM | ||
Miles Austin |
1. Miles Austin, WR | DAL | W 37-21 vs. ATL | 6 | 171 | 28.5 | 2 | 59 | 0 | |
| 2. Vincent Jackson, WR | SDG | W 37-7 at KAN | 5 | 142 | 28.4 | 1 | 51 | 0 | ||
| 3. Sidney Rice, WR | MIN | L 27-17 at PIT | 10 | 136 | 13.6 | 0 | 34 | 0 | ||
| 4. Owen Daniels, TE | HOU | W 24-21 vs. SFO | 7 | 123 | 17.6 | 1 | 42 | 0 | ||
| 5. Chad Ochocinco, WR | CIN | W 45-10 vs. CHI | 10 | 118 | 11.8 | 2 | 19 | 0 | ||
| Defensive Leaders | ||||||||||
| PLAYER | TEAM | RESULT | SOLO | AST | TOT | SACK | FF | INT | TD | |
James Farrior |
1. James Farrior, LB | PIT | W 27-17 vs. MIN | 9 | 6 | 15 | 1.0 | 0 | 0 | 0 |
| 2. Erik Coleman, S | ATL | L 37-21 at DAL | 9 | 4 | 13 | 0.0 | 0 | 0 | 0 | |
| 3. Lance Briggs, LB | CHI | L 45-10 at CIN | 7 | 6 | 13 | 0.0 | 0 | 0 | 0 | |
| 4. Robaire Smith, DE | CLE | L 31-3 vs. GNB | 9 | 3 | 12 | 0.0 | 0 | 0 | 0 | |
| 5. Tim Dobbins, LB | SDG | W 37-7 at KAN | 11 | 0 | 11 | 0.0 | 0 | 1 | 0 | |
