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| Sortable Defensive Leaders | ||||||||||
| RK | PLAYER | TEAM | RESULT | SOLO | AST | TOT | SACK | FF | INT | TD |
| 1 | Brian Robison, DE | MIN | W 21-14 vs. ARI | 7 | 2 | 9 | 3.5 | 1 | 0 | 0 |
| 2 | Daryl Washington, LB | ARI | L 21-14 at MIN | 8 | 1 | 9 | 2.0 | 0 | 0 | 0 |
| 3 | Jared Allen, DE | MIN | W 21-14 vs. ARI | 2 | 1 | 3 | 2.0 | 0 | 0 | 0 |
| 4 | Antonio Smith, DE | HOU | W 43-13 vs. BAL | 3 | 0 | 3 | 2.0 | 0 | 0 | 0 |
| 5 | Brandon Spikes, LB | NE | W 29-26 vs. NYJ | 8 | 3 | 11 | 1.0 | 0 | 0 | 0 |
| 6 | Sheldon Brown, CB | CLE | L 17-13 at IND | 9 | 1 | 10 | 1.0 | 1 | 0 | 0 |
| 7 | Michael Johnson, DE | CIN | L 24-17 vs. PIT | 5 | 3 | 8 | 1.0 | 0 | 0 | 0 |
| 8 | Lamarr Houston, DE | OAK | W 26-23 vs. JAC | 5 | 3 | 8 | 1.0 | 1 | 0 | 0 |
| 9 | David Harris, LB | NYJ | L 29-26 at NE | 7 | 1 | 8 | 1.0 | 0 | 0 | 0 |
| 10 | Cary Williams, CB | BAL | L 43-13 at HOU | 8 | 0 | 8 | 1.0 | 0 | 0 | 0 |
| 11 | NaVorro Bowman, LB | SF | W 13-6 vs. SEA | 7 | 0 | 7 | 1.0 | 0 | 0 | 0 |
| 12 | Miles Burris, LB | OAK | W 26-23 vs. JAC | 4 | 3 | 7 | 1.0 | 0 | 0 | 0 |
| 13 | Dont'a Hightower, LB | NE | W 29-26 vs. NYJ | 7 | 0 | 7 | 1.0 | 0 | 0 | 0 |
| 14 | Kamerion Wimbley, DE | TEN | W 35-34 at BUF | 4 | 2 | 6 | 1.0 | 1 | 0 | 0 |
| 15 | Justin Tuck, DE | NYG | W 27-23 vs. WSH | 4 | 2 | 6 | 1.0 | 0 | 0 | 0 |
| 16 | Anthony Spencer, LB | DAL | W 19-14 at CAR | 3 | 3 | 6 | 1.0 | 0 | 0 | 0 |
| 17 | Kyle Williams, DT | BUF | L 35-34 vs. TEN | 3 | 2 | 5 | 1.0 | 0 | 0 | 0 |
| 18 | Aldon Smith, LB | SF | W 13-6 vs. SEA | 3 | 1 | 4 | 1.0 | 0 | 0 | 0 |
| 19 | Kaluka Maiava, LB | CLE | L 17-13 at IND | 3 | 1 | 4 | 1.0 | 0 | 0 | 0 |
| 20 | Richard Seymour, DT | OAK | W 26-23 vs. JAC | 3 | 1 | 4 | 1.0 | 0 | 0 | 0 |
| 21 | Jeremy Mincey, DL | JAC | L 26-23 at OAK | 4 | 0 | 4 | 1.0 | 0 | 0 | 0 |
| 22 | Terrance Knighton, DT | JAC | L 26-23 at OAK | 3 | 1 | 4 | 1.0 | 1 | 0 | 0 |
| 23 | Michael Brockers, DT | STL | L 30-20 vs. GB | 4 | 0 | 4 | 1.0 | 0 | 0 | 0 |
| 24 | Jason Pierre-Paul, DE | NYG | W 27-23 vs. WSH | 3 | 1 | 4 | 1.0 | 1 | 0 | 0 |
| 25 | Junior Galette, DE | NO | W 35-28 at TB | 4 | 0 | 4 | 1.0 | 0 | 0 | 0 |
| 26 | Terrell Suggs, LB | BAL | L 43-13 at HOU | 3 | 1 | 4 | 1.0 | 0 | 0 | 0 |
| 27 | Connor Barwin, LB | HOU | W 43-13 vs. BAL | 4 | 0 | 4 | 1.0 | 0 | 0 | 0 |
| 28 | Cliff Avril, DE | DET | L 13-7 at CHI | 3 | 1 | 4 | 1.0 | 0 | 0 | 0 |
| 29 | Jonte Green, CB | DET | L 13-7 at CHI | 3 | 1 | 4 | 1.0 | 0 | 0 | 0 |
| 30 | Frostee Rucker, DE | CLE | L 17-13 at IND | 2 | 1 | 3 | 1.0 | 0 | 0 | 0 |
