| Passing Leaders | |||||||||||
| PLAYER | TEAM | RESULT | COMP | ATT | YDS | TD | INT | SACK | FUM | RAT | |
Philip Rivers |
1. Philip Rivers, QB | SD | L 45-38 vs. GB | 26 | 46 | 385 | 4 | 3 | 2 | 0 | 85.9 |
| 2. Tom Brady, QB | NE | L 24-20 vs. NYG | 28 | 49 | 342 | 2 | 2 | 2 | 1 | 75.4 | |
| 3. Carson Palmer, QB | OAK | L 38-24 vs. DEN | 19 | 35 | 332 | 3 | 3 | 2 | 0 | 79.7 | |
| 4. Ben Roethlisberger, QB | PIT | L 23-20 vs. BAL | 20 | 37 | 330 | 1 | 1 | 1 | 0 | 82.0 | |
| 5. Joe Flacco, QB | BAL | W 23-20 at PIT | 28 | 47 | 300 | 1 | 0 | 3 | 1 | 85.4 | |
| Rushing Leaders | ||||||||||
| PLAYER | TEAM | RESULT | CAR | YDS | AVG | TD | LNG | FUM | ||
Willis McGahee |
1. Willis McGahee, RB | DEN | W 38-24 at OAK | 20 | 163 | 8.2 | 2 | 60 | 0 | |
| 2. DeMarco Murray, RB | DAL | W 23-13 vs. SEA | 22 | 139 | 6.3 | 0 | 32 | 0 | ||
| 3. Marshawn Lynch, RB | SEA | L 23-13 at DAL | 23 | 135 | 5.9 | 1 | 29 | 0 | ||
| 4. Matt Forte, RB | CHI | W 30-24 at PHI | 24 | 133 | 5.5 | 0 | 25 | 2 | ||
| 5. Steven Jackson, RB | STL | L 19-13 at ARI | 29 | 130 | 4.5 | 0 | 19 | 0 | ||
| Receiving Leaders | ||||||||||
| PLAYER | TEAM | RESULT | REC | YDS | AVG | TD | LNG | FUM | ||
Vincent Jackson |
1. Vincent Jackson, WR | SD | L 45-38 vs. GB | 7 | 141 | 20.1 | 3 | 38 | 0 | |
| 2. Wes Welker, WR | NE | L 24-20 vs. NYG | 9 | 136 | 15.1 | 0 | 28 | 0 | ||
| 3. Julio Jones, WR | ATL | W 31-7 at IND | 3 | 131 | 43.7 | 2 | 80 | 0 | ||
| 4. Steve Breaston, WR | KC | L 31-3 vs. MIA | 7 | 115 | 16.4 | 0 | 37 | 0 | ||
| 5. Antonio Brown, WR | PIT | L 23-20 vs. BAL | 5 | 109 | 21.8 | 0 | 32 | 0 | ||
| Defensive Leaders | ||||||||||
| PLAYER | TEAM | RESULT | SOLO | AST | TOT | SACK | FF | INT | TD | |
Patrick Willis |
1. Patrick Willis, LB | SF | W 19-11 at WSH | 9 | 4 | 13 | 0.0 | 2 | 0 | 0 |
| 2. Jordan Babineaux, S | TEN | L 24-17 vs. CIN | 11 | 1 | 12 | 0.0 | 0 | 0 | 0 | |
| 3. Kevin Burnett, LB | MIA | W 31-3 at KC | 10 | 2 | 12 | 1.5 | 0 | 0 | 0 | |
| 4. Kurt Coleman, S | PHI | L 30-24 vs. CHI | 10 | 2 | 12 | 0.0 | 0 | 0 | 0 | |
| 5. Curtis Lofton, LB | ATL | W 31-7 at IND | 8 | 4 | 12 | 0.0 | 1 | 0 | 0 | |
