| Passing Leaders | |||||||||||
| PLAYER | TEAM | RESULT | COMP | ATT | YDS | TD | INT | SACK | FUM | RAT | |
Matthew Stafford |
1. Matthew Stafford, QB | DET | W 27-23 vs. STL | 32 | 48 | 355 | 1 | 3 | 1 | 0 | 69.4 |
| 2. Drew Brees, QB | NO | L 40-32 vs. WSH | 24 | 52 | 339 | 3 | 2 | 2 | 0 | 70.9 | |
| 3. Jay Cutler, QB | CHI | W 41-21 vs. IND | 21 | 35 | 333 | 2 | 1 | 2 | 0 | 98.9 | |
| 4. Robert Griffin III, QB | WSH | W 40-32 at NO | 19 | 26 | 320 | 2 | 0 | 2 | 0 | 139.9 | |
| 5. Michael Vick, QB | PHI | W 17-16 at CLE | 29 | 56 | 317 | 2 | 4 | 2 | 0 | 51.0 | |
| Rushing Leaders | ||||||||||
| PLAYER | TEAM | RESULT | CAR | YDS | AVG | TD | LNG | FUM | ||
C.J. Spiller |
1. C.J. Spiller, RB | BUF | L 48-28 at NYJ | 14 | 169 | 12.1 | 1 | 56 | 1 | |
| 2. DeMarco Murray, RB | DAL | W 24-17 at NYG | 20 | 131 | 6.6 | 0 | 48 | 0 | ||
| 3. Stevan Ridley, RB | NE | W 34-13 at TEN | 21 | 125 | 6.0 | 1 | 17 | 0 | ||
| 4. Frank Gore, RB | SF | W 30-22 at GB | 16 | 112 | 7.0 | 1 | 23 | 0 | ||
| 5. LeSean McCoy, RB | PHI | W 17-16 at CLE | 20 | 110 | 5.5 | 0 | 22 | 1 | ||
| Receiving Leaders | ||||||||||
| PLAYER | TEAM | RESULT | REC | YDS | AVG | TD | LNG | FUM | ||
Reggie Wayne |
1. Reggie Wayne, WR | IND | L 41-21 at CHI | 9 | 135 | 15.0 | 0 | 23 | 0 | |
| 2. Lance Moore, WR | NO | L 40-32 vs. WSH | 6 | 120 | 20.0 | 1 | 33 | 0 | ||
| 3. Brandon Marshall, WR | CHI | W 41-21 vs. IND | 9 | 119 | 13.2 | 1 | 24 | 0 | ||
| 4. Andre Johnson, WR | HOU | W 30-10 vs. MIA | 8 | 119 | 14.9 | 1 | 29 | 0 | ||
| 5. Kevin Ogletree, WR | DAL | W 24-17 at NYG | 8 | 114 | 14.3 | 2 | 40 | 0 | ||
| Defensive Leaders | ||||||||||
| PLAYER | TEAM | RESULT | SOLO | AST | TOT | SACK | FF | INT | TD | |
Ray Lewis |
1. Ray Lewis, LB | BAL | W 44-13 vs. CIN | 11 | 3 | 14 | 1.0 | 1 | 0 | 0 |
| 2. A.J. Hawk, LB | GB | L 30-22 vs. SF | 10 | 4 | 14 | 0.0 | 0 | 0 | 0 | |
| 3. Jerod Mayo, LB | NE | W 34-13 at TEN | 9 | 4 | 13 | 0.0 | 0 | 0 | 0 | |
| 4. Chad Greenway, LB | MIN | W 26-23 vs. JAC | 9 | 4 | 13 | 0.0 | 0 | 0 | 0 | |
| 5. Wesley Woodyard, LB | DEN | W 31-19 vs. PIT | 12 | 0 | 12 | 1.0 | 0 | 0 | 0 | |
