| Passing Leaders | |||||||||||
| PLAYER | TEAM | RESULT | COMP | ATT | YDS | TD | INT | SACK | FUM | RAT | |
Ben Roethlisberger |
1. Ben Roethlisberger, QB | PIT | L 34-31 at OAK | 36 | 49 | 384 | 4 | 0 | 1 | 0 | 123.2 |
| 2. Joe Flacco, QB | BAL | W 31-30 vs. NE | 28 | 39 | 382 | 3 | 1 | 0 | 0 | 117.7 | |
| 3. Jake Locker, QB | TEN | W 44-41 vs. DET | 29 | 42 | 378 | 2 | 0 | 0 | 1 | 113.0 | |
| 4. Tom Brady, QB | NE | L 31-30 at BAL | 28 | 41 | 335 | 1 | 0 | 2 | 0 | 101.2 | |
| 5. Peyton Manning, QB | DEN | L 31-25 vs. HOU | 26 | 52 | 330 | 2 | 0 | 3 | 0 | 83.0 | |
| Rushing Leaders | ||||||||||
| PLAYER | TEAM | RESULT | CAR | YDS | AVG | TD | LNG | FUM | ||
Jamaal Charles |
1. Jamaal Charles, RB | KC | W 27-24 at NO | 33 | 233 | 7.1 | 1 | 91 | 0 | |
| 2. Maurice Jones-Drew, RB | JAC | W 22-17 at IND | 28 | 177 | 6.3 | 1 | 59 | 0 | ||
| 3. Darren McFadden, RB | OAK | W 34-31 vs. PIT | 18 | 113 | 6.3 | 1 | 64 | 0 | ||
| 4. Andre Brown, RB | NYG | W 36-7 at CAR | 20 | 113 | 5.7 | 2 | 31 | 0 | ||
| 5. Arian Foster, RB | HOU | W 31-25 at DEN | 25 | 105 | 4.2 | 0 | 22 | 0 | ||
| Receiving Leaders | ||||||||||
| PLAYER | TEAM | RESULT | REC | YDS | AVG | TD | LNG | FUM | ||
A.J. Green |
1. A.J. Green, WR | CIN | W 38-31 at WSH | 9 | 183 | 20.3 | 1 | 73 | 0 | |
| 2. Calvin Johnson, WR | DET | L 44-41 at TEN | 10 | 164 | 16.4 | 1 | 28 | 0 | ||
| 3. Santonio Holmes, WR | NYJ | W 23-20 at MIA | 9 | 147 | 16.3 | 0 | 38 | 0 | ||
| 4. Wes Welker, WR | NE | L 31-30 at BAL | 8 | 142 | 17.8 | 0 | 59 | 0 | ||
| 5. Ramses Barden, WR | NYG | W 36-7 at CAR | 9 | 138 | 15.3 | 0 | 23 | 0 | ||
| Defensive Leaders | ||||||||||
| PLAYER | TEAM | RESULT | SOLO | AST | TOT | SACK | FF | INT | TD | |
NaVorro Bowman |
1. NaVorro Bowman, LB | SF | L 24-13 at MIN | 7 | 11 | 18 | 0.0 | 0 | 0 | 0 |
| 2. Akeem Ayers, LB | TEN | W 44-41 vs. DET | 11 | 6 | 17 | 1.0 | 0 | 0 | 0 | |
| 3. Atari Bigby, S | SD | L 27-3 vs. ATL | 11 | 4 | 15 | 0.0 | 0 | 0 | 0 | |
| 4. James Anderson, LB | CAR | L 36-7 vs. NYG | 7 | 7 | 14 | 0.0 | 0 | 0 | 0 | |
| 5. Takeo Spikes, LB | SD | L 27-3 vs. ATL | 11 | 2 | 13 | 0.0 | 0 | 0 | 0 | |
