The Lightning will seek to avenge that loss Saturday night with Steven Stamkos leading a highly productive top line and Ryan Callahan trying to build on a stellar performance.
Tampa Bay (15-6-2) managed to force overtime in Ottawa's previous visit Oct. 11, but couldn't come away with the second point in a 3-2 shootout loss. Brett Connolly tallied the tying goal with 7:26 left in regulation after the Senators scored twice in the third period.
The Lightning are 8-2-0 in Tampa since that game and have one of the Eastern Conference's best home records at 9-2-1.
They're also 10-3-1 in their last 14 overall after a 4-3 win over the New York Rangers on Wednesday. Callahan had two goals and an assist against his former team after producing one assist in his prior three games.
Callahan had eight goals and seven assists in his first 14 games but had no points against Ottawa (10-8-4).
Stamkos also had three points Wednesday, including his seventh goal in nine contests. Stamkos has scored a goal in a season-best three consecutive games, and first-line teammate Alex Killorn has four goals and two assists in his last six.
"(Callahan and Killorn) are great players in their own right, and they make me a great player as well," Stamkos said. "(Callahan) grinds it out. He goes to the net, and he can finish. (Killorn) is playing extremely well the last couple of games, and he's getting rewarded for it. He's got great skill and size.
"I think we're finding some chemistry, and, hopefully, we can keep it up."
Stamkos had one assist against the Senators in October, and has 10 goals and 11 assists in his last 18 matchups.
Ottawa enters having dropped three of four and has started 1-2-0 on a five-road trip following a 3-2 loss to Florida on Friday. Craig Anderson gave up two goals in the third period to his former team, and the Senators were outshot 18-4 in the final 20 minutes and 46-24 overall.
"We have too many excuses," coach Paul MacLean said. "We need results. We need people who want to come here and compete."
Playing on consecutive nights coupled with Anderson having given up a combined 18 goals in his last five games, MacLean could turn to Robin Lehner.
Lehner, 2-1-0 with a 2.28 goals-against average in his last three starts, was in net against Tampa Bay in October and recorded a shootout victory versus the Lightning in March.
The Lightning's top netminder Ben Bishop started the prior meeting and is 4-0-2 with a 2.55 GAA in seven starts against his former team.
Ottawa's Erik Karlsson has eight goals and five assists in his last nine games against Tampa Bay and has scored a goal in five straight matchups. He has two goals and five assists in his last 11 overall games.