Regin picked up his third power-play point of the game with an assist on Chris Phillips' goal midway through the third and the Senators extended their streak to five wins in a row with a 3-2 victory over the St. Louis Blues on Thursday night.
Regin, who opened the scoring in the first, got his second assist of the game as Phillips put a wrist shot from the slot past Chris Mason 10:29 into the third for Ottawa's third power-play goal of the game.
"Oh, it's nice," Regin said. "Everybody wants to score, obviously, especially when you help the team win. It's way more fun when you're losing five games in a row rather than losing five in a row."
The Senators had lost five in a row prior to their winning streak.
"We were on the other end of a bad streak there so it's nice to turn it around, but to turn it around with consistency," Phillips said. "We have the right consistency right now and we just want to keep that going."
Mason made 27 saves for St. Louis, which had won five of six.
"It's definitely frustrating," Mason said. "As a team I don't think we played well in the first two periods. Penalty kills is usually one of our strong suits and to give up three goals, you can't do that and expect to win."
St. Louis is 5-4-1 under coach Davis Payne, who took over behind the bench after Andy Murray was fired on Jan. 2.
"They got three power-play goals and obviously to be successful you have to get the job done on special teams," Blues forward Keith Tkachuk said.
Ottawa built a 2-0 lead midway through the second with a pair of power-play goals.
Regin, who has five points in his last two games, scored his second goal in as many games 16:09 in and assisted on Michalek's 17th goal 10:59 into the second.
Alexei Kovalev, who played his 1,200th regular-season game, set up both power-play tallies.
Regin, who had a goal and an assist in Tuesday night's 4-1 win over the Chicago Blackhawks, got credit for his eighth goal late in the first when Kovalev's centering pass went in off the Danish center's right skate.
David Perron scored an apparent tying goal for the Blues as time expired in the first. Referee Brad Watson pointed to the net to signal a goal although the green light signaling the end of the period prevented the goal judge from lighting the red light behind the net. A video review showed that time had expired before the puck crossed the goal line.
"I knew it was going to be like 50-50," Perron said. "I heard the referee, he told me I was like in the crease with point-one to go or something. It's kind of unlucky."
Michalek, who scored nine seconds after Jay McClement was sent off for high sticking, returned to the Senators' lineup after missing seven games while recovering from a concussion. He suffered the injury in a 5-2 loss in Washington on Jan.
Brewer redirected Perron's shot from the right side into the net from the edge of the crease at 18:53 to draw St. Louis to 2-1.
Blues right winger Cam Janssen and Ottawa's Matt Carkner engaged in a lengthy fight 6:06 in. ... St. Louis wrapped up a 1-2-0 trip. ... Kovalev, who has also played for the New York Rangers, Pittsburgh Penguins and Canadiens, has 406 goals and 570 assists for 976 career points.