Edmonton goalie Nikolai Khabibulin surrendered a season-high five goals on 34 shots and lost his second straight game in regulation after starting the season 7-0-2.
The Blackhawks came out firing at Khabibulin, who played four seasons in Chicago before signing as a free agent with Edmonton in July 2009.
"(Khabibulin) is one of those goalies where if he stops a couple of big ones early, he can get got and steal a game from you," Toews said. "You don't want to let that happen, so we stayed on him."
Khabibulin, who entered the game with an NHL-leading 1.18 goals-against average and .957 save percentage, has allowed eight goals in the consecutive losses after permitting just nine in his first nine games.
Oilers coach Tom Renney didn't blame his goalie, but slammed his team's performance as "awful." After a surprising start this season -- including a six-game winning streak -- Edmonton has lost four of five.
"I don't think they realize yet what it takes to win on a nightly basis," Renney said. "We have a couple of rungs to go and it starts in your own head.
"We understand the depth of the people we're playing and the experience they've had with winning and we're still working on that. But there's no excuses. We needed to man up tonight and we didn't do it."
Blackhawks defenseman Brent Seabrook sustained a lower-body injury in the second period and didn't return.
The Blackhawks jumped ahead 2-0 early in the first on goals by Toews and Montador just 36 seconds apart.
Toews opened the scoring 4:55 in when he circled the net and lofted a shot over Khabibulin's glove. Montador made it 2-0 at 5:29 when he skated around Petrell and plowed to the net.
Smyth cut it to 2-1 midway through the first by cutting to the net and stuffing a shot under Crawford. But Montador deflected in a power-play goal from the slot with 3:49 left in the period to make it 3-1.
Toews struck again 22 seconds into the second and extended Chicago's lead to 4-1 by banging a loose puck past Khabibulin's outstretched left pad.
Eberle finished a breakaway with a backhand shot at 6:17 to cut it to 4-2, but Keith connected 1:30 later on a screened drive from the left point at restore the Blackhawks' three-goal lead.
Horcoff's power-play goal, on a tip in, cut it to 5-3 with 45 seconds left in the second.
Carcillo added an empty-net goal with 1:45 left in the third to complete the scoring.
The Oilers completed a six-game trip, going 2-4-0 on the swing. ... Edmonton D Cam Barker (ankle) missed his second game. ... Chicago C Dave Bolland (right foot) sat out a third game and is day-to-day.