Two of Kopitar's goals came in the second period. Slava Voynov and former Avalanche player Brad Richardson also scored in the second period for Los Angeles (2-1-2).
Jonathan Quick stopped 27 shots including a breakaway by Chuck Kobasew early in the game to even his record at 1-1 in the preseason. Quick had six shutouts in the regular season a year ago.
Colorado goalie Semyon Varlamov, an offseason acquisition from Washington, allowed four goals on 14 shots in the second period. Colorado (1-3-0) was 0 for 6 on the power play.
Outshot 11-7 in the first period, Los Angeles cashed in on two power plays to make it 2-0.
Kopitar got his first goal of the preseason on a wrist shot from just above the right circle at 5:51 of the second period. Midway through the period, Jack Johnson set up Voynov's slap shot from the left point with Ryan Wilson off for interference.
Varlamov stopped a shot by Justin Williams. Kopitar grabbed the rebound and sent it into the net for his second goal of the game with 3:53 left in the period.
Moments later Richardson made it 4-0.
Williams made it 5-0 57 seconds into the third period. Kopitar, a 25-goal scorer in 2010-11, got his third goal of the game at 9:19.
Quick made two acrobatic saves in the last 5:28 of the third period with Dwight King serving a double minor.
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DENVER, CO - SEPTEMBER 28: Matt Duchene #9 of the Colorado Avalanche and Anze Kopitar #11 of the Los Angeles...