The Liverpool duo of Sebastian Coates and Luis Suarez was named to Uruguay's 18-man Olympics roster on Monday.
Edinson Cavani, Ajax's Nicolas Lodeiro, Bologna's Gaston Ramirez, Palermo forward Abel Hernandez and veteran Egidio Arevalo Rios were also included on the squad.
Striker Suarez is one of the three permitted over-age players selected, with Palermo's Arevalo Rios and Napoli's Cavani also included.
Veteran coach Oscar Tabarez, who guided Uruguay to a fourth-place finish at the 2010 World Cup, a 2011 Copa America triumph and a No. 2 spot in the FIFA world rankings, heads up a team that also features Diego Polenta, Matias Aguirregaray and Jonathan Urretaviscaya.
Uruguay, two-time World Cup champions, won back-to-back Olympic gold medals in 1924 and 1928. The London games will mark the first time Uruguay has qualified for the Olympics in 84 years.
Uruguay opens July 26 versus the United Arab Emirates in a group that features Senegal and host Great Britain.
The South Americans, who join fellow CONMEBOL side Brazil in the competition, finished second in the 2011 South American Under-20 Championship and won the Copa America at senior level.