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Ryan Harrison upsets John Isner

Updated: January 9, 2013, 11:40 AM ET
Associated Press

SYDNEY -- Top-seeded John Isner lost 6-4, 6-4 to fellow American Ryan Harrison in the second round of the Sydney International on Wednesday.

The exit of Isner, who was promoted to No. 1 seed after Jo-Wilfried Tsonga and Richard Gasquet withdrew, followed two more injury withdrawals: second-seeded and 2011 Sydney champion Gilles Simon (neck) and sixth-seeded Radek Stepanek (back).

Isner, who withdrew from the Hopman Cup mixed-team competition in Perth last week with a right ...

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