Players will start gathering Sunday in Cary, N.C., for training. The U.S. plays Argentina on March 26 in East Rutherford, N.J., and Paraguay three days later in Nashville, Tenn.
Three players with no previous national team experience were selected Wednesday by U.S. coach Bob Bradley: Nuremberg defender Timothy Chandler, Duisburg goalkeeper David Yelldell and Norwich defender Zak Whitbread.
Goalkeeper Marcus Hahnemann and defender Jay DeMerit were selected for the first time since the World Cup. Donovan and Dempsey had not been picked together since the tournament in South Africa last June.
Eight players are based in England, four in Germany, and one each in Belgium, Denmark, France, Mexico, the Netherlands, Norway, Scotland and Turkey.
The U.S. is preparing for the CONCACAF Gold Cup, where it has first-round matches against Canada on June 7 at Detroit, Panama four days later at Tampa, Fla., and Guadeloupe on June 14 at Kansas City, Kan.
Argentina, led by two-time FIFA player of the year Lionel Messi, and Paraguay are getting ready for the Copa America. Argentina hosts South America's championship, which starts July 1.
Goalkeepers: Marcus Hahnemann (Wolverhampton, England), Tim Howard (Everton, England), David Yelldell (Duisburg, Germany)
Defenders: Carlos Bocanegra (Saint-Etienne, France), Jonathan Bornstein (UANL Tigres, Mexico), Timothy Chandler (Nuremberg, Germany), Steve Cherundolo (Hannover, Germany), Jay DeMerit (Vancouver), Oguchi Onyewu (Twente, Netherlands), Tim Ream (New York), Jonathan Spector (West Ham, England), Zak Whitbread (Norwich, England)
Midfielders: Michael Bradley (Aston Villa, England), Clint Dempsey (Fulham, England), Mikkel Diskeruud (Stabaek, Norway), Landon Donovan (Los Angeles), Maurice Edu (Glasgow Rangers, Scotland), Benny Feilhaber (Aarhus, Denmark), Stuart Holden (Bolton, England), Jermaine Jones (Blackburn, England), Sacha Kljestan (Anderlecht, Belgium)
Forwards: Juan Agudelo (New York), Jozy Altidore (Bursaspor, Turkey), Edson Buddle (Ingolstadt, Germany)
Copyright 2011 by The Associated Press
MORE SPORTS HEADLINES
- Ribery, Benzema charged with soliciting minor
- Ex-U.S. coach denies Solo's shoving allegation
- Messi, Ronaldo, Iniesta UEFA award finalists
- Kompany: Van Persie would boost any team
MOST SENT STORIES ON ESPN.COM