Sharapova used her strength to move Perry around the court and keep her off balance, advancing in less than an hour.
"I thought I was very aggressive," Sharapova said. "To play every point with a strong mentality in every match, it's impossible to keep going up, up, up and hit a winner on every single ball. So, when I did feel like I maybe missed a few, I still was going for it. I wasn't tentative."
Sharapova was able to work on various parts of her game, but stopped short of saying it was an easy win.
"It's just about going out there and doing the right things," she said. "Competing no matter who's across the net."
In the Regions Morgan Keegan Championships -- the men's side of the Memphis stop -- sixth-seeded John Isner beat 17-year-old qualifier Ryan Harrison 6-1, 7-5, and No. 3 seed Radek Stepanek advanced with a 7-5, 4-6, 6-4 victory over South Africa's Kevin Anderson.