Andy Roddick is only 3-21 lifetime against Roger Federer. But in the final year of his career at the 2012 Masters Tournament in Miami, Roddick produced a thrilling victory 7-6 (4), 1-6, 6-4. Federer couldn't even force a break point in Roddick's final four service games. Roddick punctuated the rare victory with a 134-mph serve on the final point.
Afterward, Federer said: "I feel like I lost against a former No. 1, not that I lost against a guy ranked 30 in the world."