Time is ripe for Safina to take advantage of ailing tour members

Tournament: U.S. Open
Surface: Hard
Draw: 128
Top seeds: Ana Ivanovic, Jelena Jankovic, Svetlana Kuznetsova, Serena Williams

Who's on first? Ana Ivanovic, for the time being, in what's turned out to be a wacky season in the women's game.

Ivanovic missed the Olympics with a thumb injury, fellow Serb Jelena Jankovic's is dealing with a calf strain and the Williams sisters have gimpy knees. Much like the Olympics, it's a battle of the fittest.

Jankovic, if healthy, won't have a better chance to reach a first Grand Slam final. Almost all of the major contenders are in Ivanovic's top half.

First quarter: Safina in pole position
After winning a silver medal at the Olympics, Dinara Safina lavished heavy praise on her coach, Zeljko Krajan.

"I have to thank God that I met him,'' Safina said.

Imagine her words if the Russian can win a Grand Slam.

Safina, who, not surprisingly, admitted she was tired following a hectic three months, is still the hottest player in the women's game -- and vitally, healthy.

There's little early danger for the Russian. In fact, French teen Alize Cornet, better on clay, appears to be her only road block before the quarterfinals.

Ivanovic is meant to be waiting, though the thumb injury puts that into question. Big-hitting Aussie Casey Dellacqua looms in the second round, sentimental favorite Amelie Mauresmo might surface in the third and dark horse Nadia Petrova is a potential opponent in the fourth.

Prediction: Safina

Second quarter: Williams & Williams
We could be in store for a first Grand Slam quarterfinal meeting between sisters Venus and Serena Williams. Both show up in this section.

Like Safina, Serena, who blew a set and break lead to eventual champion Elena Dementieva in the Olympic quarterfinals, has an easy looking first three rounds. Ukraine's Julia Vakulenko, a possible second-round foe and one of the breakout performers of 2007, has gone 3-10 in 2008 thanks largely to a wrist injury.

Venus starts against the attacking Samantha Stosur -- Serena crushed the Aussie in Beijing -- and is slated to face 27th seed Alona Bondarenko, a doubles opponent in China, in the third round. Bondarenko has cooled in the second half of 2008.

To the fourth round, then, and if Venus is off her game slightly (remember, she hasn't won a non-grass-court major since 2001), Pole Agnieszka Radwanska or feisty Slovak Dominika Cibulkova, two teenagers, could knock her off.

Serena over Cibulkova in the fourth round.

Prediction: Serena Williams

Third quarter: It's up to Elena
Here's what Dementieva had to say after winning gold in China: "That was the biggest goal in my career. I don't know what to dream about [now]. There is nothing compared to the gold medal, nothing.''

Hmm. You think she'll be motivated for New York?

If not, Italian wall Francesca Schiavone should fancy her chances in the third round. If yes, Dementieva should ease into the quarterfinals. Her only serious threat is the slumping third-seed Svetlana Kuznetsova, last year's finalist. Other seeds in the not-so-packed section are Schiavone, Shahar Peer, Anna Chakvetadze, Patty Schnyder, Maria Kirilenko and Katarina Srebotnik.

Peer and the inconsistent Kirilenko face tough first-round opponents in Li Na and Tamira Paszek, respectively.

Prediction: Kuznetsova

Fourth quarter: Jelena's gift
A few dark horses lurk in Jankovic's quarter, but the No. 2 should cope -- again, assuming the calf is better.

Jankovic, so nearly a U.S. Open finalist two years ago, potentially faces Chinese battler Zheng Jie in the third round. In the fourth, it could be either Victoria Azarenka or fellow teen Caroline Wozniacki, on the other side of the net at Wimbledon when Jankovic fell badly and hurt her knee.

Another sentimental favorite, Lindsay Davenport, the 1998 champion hindered by a knee injury herself, has a tough start against rising Canadian Aleksandra Wozniak.

Given her path, Vera Zvonareva, seeded eighth, has a decent shot of following up her Olympic bronze with a fourth-round showing.

Prediction: Jankovic

Kuznetsova, the 2004 U.S. Open champion, has had trouble winning big matches the last two years; Jankovic is in the same boat.

Just imagine how much fun watching this one would be.

For what it's worth, Kuznetsova leads their head-to-heads 3-2. Safina downed Williams the last time they met, on clay this year, which won't hurt her confidence. At this point, she's also the steadier.

Prediction: Safina, Jankovic to advance

Safina got her feet wet at the French Open, when the tennis gods were seemingly on her side, by reaching a first Grand Slam final. Instead of suffering a letdown, she's only improved. If Safina is on her game, Jankovic will struggle, as she does with other big hitters.

Prediction: Safina

Ravi Ubha is a frequent contributor to ESPN.com.