Will New England get off on the right foot or will Oakland and Randy Moss take care of business on the road? How will Ben Roethlisberger's second season begin as Pittsburgh heads to Tennessee? What about the NFC Championship Game rematch between Philadelphia and Atlanta? And don't forget the Saints, playing with heavy hearts at Carolina.
Simply scroll down the page, make your picks and check back at the end of the weekend to see how SportsNation fared!