It's hard to argue given Notre Dame's resurgence of late and their legitimate chances of erasing USC's 27-game win streak and possibly derailing the Trojans' hopes of a third consecutive national championship.
Not only do the Fighting Irish have one of the best offenses in the nation to match up against USC's Matt Leinart-Reggie Bush Show, but the speedster Bush is battling a bruised knee which could limit his productivity. Notice, we said could.
Will the game live up to the hype? What kind of impact will Reggie Bush have? Who will come out on top? Cast your vote and settle in for another great weekend of college football action.
Pick the winners of every Top 25 game this weekend.