Maybe it's just a reflex to see Florida State's name and click on them, but No. 23 Boston College went down to Tallahassee and handed the 'Noles their third loss of the season. That game had just a 52 percent confidence level on the picks sheet. In another game that proved tough to handicap, SportsNation incorrectly chose Georgia Tech to defeat Clemson - with a confidence rate of 53 percent. Not only did that not happen, but Clemson routed the Yellow Jackets. The only other game that SportsNation picked incorrectly was Washington State's shocking dominance of then-No. 16 Oregon in Pullman.
This week features just one matchup between ranked opponents - No. 19 Oklahoma at No. 23 Missouri. How will the Sooners fare without Adrian Peterson and the Tigers without Brian Smith? Other top matchups include Miami (Fla.) at Georgia Tech and Tennessee at South Carolina.
Scroll down the page, make your picks and check back at the end of the weekend to see how your picks stacked up.
SportsNation's 2006 Pick 'Em percentage: .870 (140-for-161)