Dallas Cowboys at New York Giants
Eli Manning has burnished his clutch reputation, but is this the year Tony Romo takes over?
Vote: Five questions for Cowboys at Giants
Washington Redskins at New Orleans Saints
The Saints are a perennial threat to win the Super Bowl, but will their coaching situation get the best of them?
Vote: Five questions for Redskins at Saints
Buffalo Bills at New York Jets
Mark Sanchez and Tim Tebow have received the lion's share of coverage this preseason, but is Ryan Fitzpatrick better than both of them?
Vote: Five questions for Bills at Jets
San Francisco 49ers at Green Bay Packers
San Francisco's defense is its main weapon, but can it shut down Aaron Rodgers and the high-flying Packers?
Vote: Five questions for 49ers at Packers
Pittsburgh Steelers at Denver Broncos
Peyton Manning has looked good in preseason, but will he return to form when things get truly serious?
Vote: Five questions for Steelers at Broncos
Week 1 NFL Pick 'Em
Week 1 is sure to generate a lot of storylines to kick off the regular season.
Vote: Pick the winners in every Week 1 game