Ole Miss at No. 1 Alabama
Alabama's goal is the national championship, but it's also striving for an unbeaten season.
Vote: Five questions for Ole Miss at Alabama
Tennessee at No. 5 Georgia
Georgia is battling Florida and South Carolina for the top position in the SEC East.
Vote: Five questions for Tennessee at Georgia
No. 14 Ohio State at No. 20 Michigan State
This is a classic unstoppable force/immovable object matchup, with the Buckeyes' offense looking to crack the Spartans' defense.
Vote: Five questions for Ohio St. at Michigan St.
No. 25 Baylor at No. 9 West Virginia
Geno Smith has been lighting up opposing defenses, but does that make him the favorite to win the Heisman trophy?
Vote: Five questions for Baylor at West Virginia
Week 5 College Football Pick 'Em
Do you see any upsets brewing in the big-time Top 25 games?
Vote: Pick the winner in every Top 25 game