Atlanta Falcons at Washington Redskins
Michael Turner has been the Falcons' go-to guy on offense, but the Redskins' rushing defense has been strong this season.
Vote: Five questions for Falcons at Redskins
Philadelphia Eagles at Pittsburgh Steelers
Michael Vick has had a bit of a problem with turnovers this season -- he has 11 fumbles and interceptions so far.
Vote: Five questions for Eagles at Steelers
Denver Broncos at New England Patriots
Tom Brady and Peyton Manning are among the greatest quarterbacks of all time, even as they're getting on a bit in age.
Vote: Five questions for Broncos at Patriots
Buffalo Bills at San Francisco 49ers
The Bills suffered a total second-half breakdown on both sides of the ball in their 52-28 loss to the Patriots last week.
Vote: Five questions for Bills at 49ers
Week 5 NFL Pick 'Em
Do you see any upsets brewing among the big games this week?
Make your pick for each Week 5 matchup!