The one variable NFL coaches can't control is also the one that can have the biggest impact on a team's season: Losing key players to injury. The Bears, Rams, Eagles and Colts know that all too well, as all four teams lost key performers for weeks or for the season. The Rams will have to replace QB Sam Bradford, while the Colts lost lost Reggie Wayne. The Eagles' QB situation was muddled when Nick Foles' concussion reopened questions about who should start in Philly. And the Bears, already fighting injury losses on defense, will be without quarterback Jay Cutler and linebacker Lance Briggs for weeks. Which of these teams was dealt the lousiest cards?
The hits keep on coming
Josh McCown will step in at QB while Jay Cutler recovers from a groin tear.
Tough break for Indy
With leading WR Reggie Wayne out for the season, the Colts will be counting on T.Y. Hilton and Darius Heyward-Bey.
With Sam Bradford lost for the season, the Rams must decide if they'll turn the team over to backup Kellen Clemens.
Who gets the start?
Nick Foles' concussion could put Michael Vick back in as starter in Philly. Should it?