The eighth-ranked Italian lost to Dushevina for the third time in four meetings.
Second-seeded Marion Bartoli advanced at the Olympic Park by beating Nuria Llagostera-Vives of Spain 6-2, 6-2.
Three other seeded players also advanced. No. 3 Julia Goerges of Germany defeated Yunka Sema of Japan 6-1, 6-1, Polona Hercog of Slovenia eliminated Zuzana Kucova of Slovakia 6-0, 6-2, and Irina-Camelia Begu of Romania defeated Akgul Amanmuradova of Uzbekistan 6-1, 6-3.